P-611 Progestin-Primed Ovarian Stimulation is a non-inferior alternative to the GnRH Antagonist Protocol in patients undergoing ovarian stimulation: a propensity score weighting analysis

Abstract Study question To evaluate the effectiveness of progestin-primed ovarian stimulation (PPOS) protocol versus gonadotropin-releasing hormone antagonist (GnRH-ant) in stimulation. Summary answer The PPOS with dydrogesterone provided similar embryo outcomes to GnRH-ant protocol. serum LH concentration during using was well-controlled. What is known already Since Yanping Kuang's proposal 2015, several studies on this treatment regimen have been published. Although it has suggested that were comparable those regimen, findings limited due differences study design, patient characteristics, dosage and type progestins. While medroxyprogesterone acetate often used studies, seen far less popularity. Additionally, a relatively weak inhibitor compared MPA, leading concern about increased incidence unexpected surge size, duration We conducted retrospective among women who underwent In Vitro Fertilization at Assisted Reproduction Center, Tam Anh General Hospital, Vietnam from January 1st, 2022 October 10th, 2022. Participants/materials, setting, methods included 804 patients stimulation, which 208 (30 mg dydrogesteron per day beginning until trigger-day) 598 (cetrorelix 0.25 daily, 6 trigger-day). addition unadjusted analysis, we propensity score weighting account for confounding might possibly remain. Main results role chance Baseline characteristics both groups. adjusted mean number good cleavage embryos (6.33) non-inferior (6.44; ratio two means 1.02, 95%CI 0.92, 1.13). trigger-day estradiol level higher (4,420 vs 3,830 pmol/L GnRH-ant) despite total follicle stimulating dose fewer days overall oocytes retrieved, MII oocytes, embryos, blastocysts, blastocysts between protocols. None had an surge, levels decreased slightly Limitations, reasons caution Due nature did not record progesterone regimen; therefore, identifying based feasible. Furthermore, transfer. Wider implications These supported use as cheap effective alternative clinicians clinical practice. indication freeze-all embryo, could be recommended. Trial registration Not Applicable